Tomar 1 cápsula per day, together with a meal. Preferably in the morning or early afternoon.

Benefits of Vitamin D3 Supplementation

Improves Mood

Studies found that vitamin D supplementation helps reduce anxiety and depression in people with vitamin D deficiency. [53][54]

Has a Preventive Effect Against Flu

Vitamin D3 supplementation reduces the likelihood of developing the flu by up to 36%, according to a meta-analysis of randomized controlled studies involving 10 studies and a total of 4859 participants. [28]

Protects Against Respiratory Infections

A study concluded that supplementing with vitamin D can reduce the risk of respiratory infections by up to 70%, especially in individuals with very low vitamin D levels. The study involved over 10,000 participants in 25 clinical trials. [60]

Reduces Cancer Mortality

This is the area where vitamin D3 has the strongest scientific evidence related to the development and prevention of cancer. Various studies show that vitamin D3 supplementation significantly reduces colon cancer mortality, as well as its development. [29][31][32][33][34]

Significantly Reduces Inflammation

Vitamin D3 supplementation is capable of substantially reducing inflammation levels in the body, according to several meta-analyses of randomized controlled trials.
This effect is observed in virtually all studies conducted in this field. [35][36][37][38]

Reduces Migraine Incidence

These meta-analyses of randomized controlled trials have shown that vitamin D3 supplementation significantly reduces the incidence of migraines. [39][40]

Reduction in Mortality

Vitamin D3 supplementation appears to significantly reduce all-cause mortality, according to 80 randomized controlled studies. [27]
Other studies have shown that vitamin D3 supplementation significantly reduced mortality from various cancers. [30][35]

What is Vitamin D3?

Vitamin D3, scientifically known as cholecalciferol, is a vital nutrient for well-being, produced in the skin through exposure to sunlight; it plays several crucial roles in our body. For example, it facilitates calcium absorption to strengthen bones, enhances immune system function, promotes overall health, and contributes to mood regulation through its involvement with neurotransmitters.
However, many people do not get enough sun exposure, especially those who live in regions with low sunlight or who spend most of their time indoors.

Prevalence of Vitamin D3 Deficiency

A study conducted in Portugal showed that 66% of Portuguese adults had a deficiency in Vitamin D3. [2]
Studies in the European population show that there is an epidemic of vitamin D3 deficiency, with 40% of Europeans having vitamin D3 levels considered insufficient. These values are more prevalent in the winter due to lack of sun exposure. [1]. Sendo estes valores mais prevalentes no inverno, devido à ausência da luz solar.

Optimal Levels and Deficiency of Vitamin D3

Deficiency is considered when levels are below 29 ng/mL (75nmol/L). [48]
Optimal levels range from 32ng/mL to 100ng/mL (80nmol/L–250nmol/L). [49]

Why Combine Vitamin D3 with Vitamin K2?

Vitamin D3 increases calcium absorption in the intestines, and in high amounts, this can lead to hypercalcemia [20][21][22], which is excess calcium in the bloodstream, especially when combined with calcium intake. This process may lead to arterial calcification [23].
Vitamin K2, being a strong inhibitor of arterial calcification, prevents this process from occurring. It also directs the excess calcium to the bones. [24][26]
Vitamin K2 has been shown to reduce calcification markers in controlled studies. [19][25]

Importance of the Form of Vitamin K2

Not all forms of vitamin K2 are equally bioavailable, so it's important to read the label carefully to know exactly which form of K2 is present.
Vitamin K2 MK4 is far inferior and has no effect on vitamin K2 levels when compared to the MK7 form, which is the one we use in our product. [26]

Problems Associated with Vitamin D3 Deficiency

The list of problems associated with vitamin D3 deficiency is extensive, and levels should always be monitored to ensure they are within a healthy range.
A deficiency in this vitamin increases the risk of bone fractures [41], chronic kidney disease [42], diabetes [43], multiple sclerosis [44], mortality [45], rickets [46], osteoporosis [47], depression [55] and more.

Is the Vitamin D3 dosage in this product safe?

EFSA (European Food Safety Authority) has set 4,000 IU as the acceptable upper limit, even for children over 11 years old. [52]
Doses below 10,000 IU per day pose a very low risk of developing vitamin D3 toxicity. [50]