Health Essentials

NAC Synergic

Name: NAC Synergic
Brand: INSYGMA Nutrition
SKU: 11132025
Price: 12.99 EUR
Availability: OutOfStock
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Cellular Antioxidant Defense
Powerful Liver Support
Manufactured in GMP+FSSC-Certified Facilities

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NAC Synergic supports natural glutathione production, reduces the oxidative stress and strengthens cellular defenses.

WHAT MAKES THIS DIFFERENT

It’s not just NAC. It’s a more complete approach.

From the age of 40, the body loses its ability to produce glutathione, the master antioxidant that protects cells and keeps mitochondria functioning. GlyNAC corrects this deficiency at its source, providing the two deficient precursors: glycine and N-acetylcysteine. The effect is not limited to one area. It is systemic.

+164% Intracellular glutathione

−72% Oxidative stress

−64% Insulin resistance

Put simply: this is not “just another antioxidant”. It is a combination designed to support what matters most with age: cellular protection, energy, function, and clarity.

Cellular defense

Energy

Physical function

Mental clarity

Six areas in which GlyNAC works, all documented in clinical trials.

Cellular defense Restores intracellular glutathione, the master antioxidant that becomes severely deficient from the age of 40.

+164% Muscle glutathione vs. baseline

Mitochondrial energy Restores the mitochondria’s ability to oxidize fat. Useful energy, not stimulation.

+78% Mitochondrial fatty acid oxidation

Physical function Grip strength, walking speed, and exercise capacity improve too.

+29% Grip strength (non-dominant hand)

Mental clarity Improvements in validated cognitive tests and an increase in BDNF, the marker associated with memory.

+51% Plasma BDNF

Metabolism Reduces insulin resistance, fasting insulin, and waist circumference. Without changing the diet.

−64% Insulin resistance (HOMA-IR)

Inflammation & blood vessels Reduces markers of chronic inflammation (IL-6, TNFα, CRP) and improves endothelial function.

−57% Endothelial dysfunction (sICAM-1)

Consistent results in clinical trials with adults aged 60+ over 16–24 weeks. Kumar et al., Journal of Gerontology: Medical Sciences, 2023. Placebo-controlled RCT. Related studies in Clinical and Translational Medicine (2021) and Biomedicines (2020).

01 Product Description & Science

Why does NAC fail on its own?

Most people take NAC because they believe it increases glutathione levels: the body’s "master antioxidant". But human studies repeatedly show that this does not happen. NAC enters the body, cysteine increases… but glutathione does not increase.

METABOLIC BOTTLENECK

NAC is not the problem.
The problem is that the rate-limiting factor in production is missing: glycine. ¹

Without enough glycine, the body cannot complete the glutathione molecule, even with abundant NAC.

The result? NAC alone fails.

01 It rises in the blood… but does not increase glutathione

In a study of immunocompromised patients, NAC increased cysteine in the blood, but glutathione remained unchanged.

"Despite the increase in cysteine… there was no significant increase in glutathione in plasma or cells."

^{Witschi et al. 1995}

02 Even after 6 months of continuous use… nothing changes

A 6-month clinical trial of NAC (600 mg, 3×/day) showed exactly the same:

"N-acetylcysteine supplementation… did not increase significantly glutathione concentrations."

^{Bernhard et al. 1998}

03 NAC only prevents glutathione from falling

Under chemical stress, NAC prevents glutathione from falling but does not increase it above normal levels.

"NAC prevented the decline in glutathione but did not increase it…"

^{Pickering et al. 2019}

04 Even injected NAC does not work

Even with intravenous doses (impossible to achieve orally), the result is the same:

"NAC infusion… did not affect whole-blood glutathione."

^{Medved — Doctoral Thesis}

Conclusion: increasing glutathione is not just about "taking NAC".
Without enough glycine, synthesis does not start and NAC goes unused.

The Modern and Effective Way to Increase Glutathione

If NAC alone does not increase glutathione, what is the solution?

The science is clear: glutathione only increases when NAC and glycine are supplied together. This combination, known in the scientific literature as GlyNAC, unlocks the rate-limiting step in synthesis.

CLINICAL SOLUTION

GlyNAC provides exactly what the body needs:
NAC (cysteine) + Glycine in the right ratio, finally allowing the molecule to be completed.

The result is consistent: Glutathione rises, oxidative stress falls.

Studies show real increases

GlyNAC Trials ¹ show simultaneous improvements in:

✔ Intracellular glutathione
✔ Oxidative stress
✔ Insulin sensitivity
✔ Mitochondrial function

NAC Synergic: Maximize Synthesis

GlyNAC works because it provides the essential building blocks. But INSYGMA went further: we reinforced the pathway with enzymatic cofactors that make production more efficient, stable, and continuous.

NAC PRECURSOR 1

The most effective source of cysteine. The essential starting building block.

Glycine CRITICAL

The key that unlocks synthesis. Without it, NAC fails.

Vitamin B6 (P5P) COFACTOR

Active form. Optimizes sulfur metabolism.

Vitamin B2 (R5P) RECYCLING

Essential for recycling oxidized glutathione.

Molybdenum DETOX

Processes NAC by-products without metabolic fatigue.

Selenium DEFENSE

Fuel for the glutathione peroxidase enzyme.